The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXXVI.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Lee MY, Park KA, Yeo SJ, Kim SH, Goong HJ, Jang AS, Park CS

Bronchospasm and anaphylactic shock following lidocaine aerosol inhalation in a patient with butane inhalation lung injury.

Allergy, asthma & immunology research. 2011;3(4):280-2

Soong WJ, Lee YS, Soong YH, Tsao PC, Yang CF, Jeng MJ, Peng YY

Life-threatening anaphylactic reaction after the administration of airway topical lidocaine.

Pediatric pulmonology. 2011;46(5):505-8

Bonnet MC, du Cailar G, Deschodt J

[Anaphylaxis caused by lidocaine].

Annales francaises d'anesthesie et de reanimation. 1989;8(2):127-9