The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIV.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Mustafa Z, Ahmad M, Alkhatib M, Haq IU, Allangawi M, Thomas M, Hameed M

Drug-Induced Pneumonitis Secondary to Ribociclib in a Patient With Metastatic Breast Cancer.

Cureus. 2026;18(4):e106954

Ünsal O, Özet A

Ribociclib-induced pulmonary infiltrates in a patient with breast cancer.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2023;29(6):1537-1540

Rajendran A, Kunoor A, Pushpa Ragahavan R, Keechilat P

Ribociclib-associated organising pneumonia.

BMJ case reports. 2021;14(12)