The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

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Multiple organ dysfunction/failure (MODS/MOF)

Publications

Valido A, Boncompagni AC, Tsang M, Hume P

There's the Rub: a narrative review of the benefits and complications associated with Vicks VapoRub use.

PeerJ. 2025;13:e19105

Cordoba Torres IT, Marino-Nieto J, Barkin HB, Fort AC, Cobas M

Vicks® VapoRub™ intoxication: An unusual presentation of multiorgan failure.

Journal of clinical anesthesia. 2018;48:46-47