The Drug-Induced Cardiotoxicity Website and App

Excipients, erroneously/deliberately administered i.v.

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXXIII.n

Path: Foreign body embolism, microangiopathy, vasculopathy

Publications

Hossein-Zadeh Z, Shuman MJ, Rapkiewicz A

Fatal Excipients: An Autopsy Case Series of Excipient Lung Disease.

The American journal of forensic medicine and pathology. 2022;43(1):81-89

Cook CM, Simpson SQ, Satterwhite L

Excipient-Induced Pulmonary Vascular Disease: An Underrecognized and Deadly Complication of Opioid Addiction.

Lung. 2021;199(4):363-368