The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIV.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Tanaka N, Kitahara K, Kusunoki Y, Sunaga T

Drug-Induced Lung Injury With Drug Eruption Due to Apalutamide Followed by Switch to Bicalutamide: A Case Report.

Cureus. 2025;17(9):e91764

Kirishima F, Shigematsu Y, Kobayashi K

Interstitial lung disease induced by apalutamide therapy for castration-resistant prostate cancer: A report of a rare case.

IJU case reports. 2022;5(3):153-155

Kobe H, Tachikawa R, Masuno Y, Matsunashi A, Murata S, Hagimoto H, Tomii K

Apalutamide-induced severe interstitial lung disease: A report of two cases from Japan.

Respiratory investigation. 2021;59(5):700-705