The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIV.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Lee IH, Kang GW, Kim KC

Hypersensitivity pneumonitis associated with azathioprine therapy in a patient with granulomatosis with polyangiitis.

Rheumatology international. 2016;36(7):1027-32

Bodelier AG, Masclee AA, Bakker JA, Hameeteman WH, Pierik MJ

Azathioprine induced pneumonitis in a patient with ulcerative colitis.

Journal of Crohn's & colitis. 2009;3(4):309-12

Nagy F, Molnár T, Makula E, Kiss I, Milassin P, Zöllei E, Tiszlavicz L, Lonovics J

[Azathioprine-associated interstitial pneumonitis].

Orvosi hetilap. 2006;147(6):259-62

Perreaux F, Zenaty D, Capron F, Trioche P, Odièvre M, Labrune P

Azathioprine-induced lung toxicity and efficacy of cyclosporin A in a young girl with type 2 autoimmune hepatitis.

Journal of pediatric gastroenterology and nutrition. 2000;31(2):190-2

Krowka MJ, Breuer RI, Kehoe TJ

Azathioprine-associated pulmonary dysfunction.

Chest. 1983;83(4):696-8

Carmichael DJ, Hamilton DV, Evans DB, Stovin PG, Calne RY

Interstitial pneumonitis secondary to azathioprine in a renal transplant patient.

Thorax. 1983;38(12):951-2

Weisenburger DD

Interstitial pneumonitis associated with azathioprine therapy.

American journal of clinical pathology. 1978;69(2):181-5