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The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.b

Pulmonary edema, noncardiogenic (NCPE)

Publications

Zhong Z, Liu M, Zhong Q, Zhou M, Di X

Drug-induced pulmonary edema: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS).

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2025;58:e14566

Ali AK

Pharmacovigilance Analysis of Serious Adverse Events Reported for Biologic Response Modifiers Used as Prophylaxis against Transplant Rejection: a Real-World Postmarketing Experience from the US FDA Adverse Event Reporting System (FAERS).

International journal of organ transplantation medicine. 2013;4(2):62-71

Tu GW, Ju MJ, Xu M, Rong RM, Zhu TY, Luo Z

Antithymocyte globulin-induced acute respiratory distress syndrome after renal transplantation: a case report.

Chinese medical journal. 2012;125(9):1664-6

Parikh BK, Bhosale GP, Shah VR

Anti-thymocyte globulin induced non-cardiogenic pulmonary edema during renal transplantation.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine. 2011;15(4):230-2

Goligher EC, Cserti-Gazdewich C, Balter M, Gupta V, Brandwein JE

Acute lung injury during antithymocyte globulin therapy for aplastic anemia.

Canadian respiratory journal. 2009;16(2):e3-5

Maillard N, Foucher P, Caillot D, Durand C, Sgro C, Camus P

Transient pulmonary infiltrates during treatment with anti-thymocyte globulin.

Respiration; international review of thoracic diseases. 1999;66(3):279-82