The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.l

Cardiac- cardiorespiratory/pulmonary arrest

Publications

Jin C, Zahid E, Sherazi A, Majumder MR, Bedi P

Cardiac Arrest Due to Benzonatate Overdose.

The American journal of case reports. 2019;20:640-642

Yoshioka I, Surmaitis R, Katz KD

A 17-Year-Old Girl With Cough--Pulseless After Drug Overdose. Sodium benzonatate overdose.

Pediatric emergency care. 2016;32(3):197-9

Cohen V, Jellinek SP, Stansfield L, Truong H, Baseluos C, Marshall JP

Cardiac arrest with residual blindness after overdose of Tessalon® (benzonatate) perles.

The Journal of emergency medicine. 2011;41(2):166-71