The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXXVIII.m

Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

Publications

Jin C, Zahid E, Sherazi A, Majumder MR, Bedi P

Cardiac Arrest Due to Benzonatate Overdose.

The American journal of case reports. 2019;20:640-642

Thimann DA, Huang CJ, Goto CS, Feng SY

Benzonatate toxicity in a teenager resulting in coma, seizures, and severe metabolic acidosis.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG. 2012;17(3):270-3