The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIV.b

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)

Publications

Pepels MJ, Boomars KA, van Kimmenade R, Hupperets PS

Life-threatening interstitial lung disease associated with trastuzumab: case report.

Breast cancer research and treatment. 2009;113(3):609-12

Vahid B, Mehrotra A

Trastuzumab (Herceptin)-associated lung injury.

Respirology (Carlton, Vic.). 2006;11(5):655-8