The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXXVI.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Can be near-fatal or fatal (PMID 19210362)

Publications

Wu BL, He WX, Ke M, Shang-Guan XF, He GF, Huang R

A Retrospective Analysis on 1330 Adverse Event Reports of Qingkailing in China: Further Perception of Its Risks and Rational Use.

Current medical science. 2018;38(6):1103-1108

Zhan Q

Literature analysis of Acanthopanax anaphylactic shock in China.

Journal of traditional and complementary medicine. 2015;5(4):253-7

Ji K, Chen J, Li M, Liu Z, Xia L, Wang C, Zhan Z, Wu X

Comments on serious anaphylaxis caused by nine Chinese herbal injections used to treat common colds and upper respiratory tract infections.

Regulatory toxicology and pharmacology : RTP. 2009;55(2):134-8

Ji KM, Li M, Chen JJ, Zhan ZK, Liu ZG

Anaphylactic shock and lethal anaphylaxis caused by Houttuynia Cordata injection, a herbal treatment in China.

Allergy. 2009;64(5):816-7