The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XIV.d

Eosinophilic pleural effusion

Publications

Joshi P, Kasmani R, Hollingsworth J, Fernandes K, Mahajan K

Divalproex sodium-induced eosinophilic pleural effusion.

American journal of therapeutics. 2009;16(6):593-5

Tryfon S, Saroglou M, Kazanas K, Mermigkis C, Psathakis K, Galanis N

Sodium valproate as a cause of recurrent transudative pleural effusion: a case report.

Journal of medical case reports. 2009;3:51

Bullington W, Sahn SA, Judson MA

Valproic acid-induced eosinophilic pleural effusion: a case report and review of the literature.

The American journal of the medical sciences. 2007;333(5):290-2

Catalán Alcántara A, Sánchez Pérez M, Domezain del Campo M, Ruiz Irastorza G

Eosinophilic pleural effusion secondary to treatment with valproic acid.

Actas espanolas de psiquiatria. 2005;33(6):401-2

Kravetz JD, Federman DG

Valproic acid-induced eosinophilic pleural effusion.

Southern medical journal. 2003;96(8):803-6

Chiles C, van Wattum PJ

Pleural fluid eosinophilia with combined pharmacotherapy.

Psychosomatics. 2003;44(5):436-7

Kaufman J, O'Shaughnessy IM

Eosinophilic pleural effusion associated with valproic acid administration.

Southern medical journal. 1995;88(8):881-2