The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXII.b

ARDS - Acute lung injury

Publications

Martin TR, Sandblom RL, Johnson RJ

Adult respiratory distress syndrome following thrombolytic therapy for pulmonary embolism.

Chest. 1983;83(1):151-3

Kerstein MD, Adinolfi MF

Pulmonary dysfunction associated with streptokinase therapy.

Archives of surgery (Chicago, Ill. : 1960). 1986;121(7):852-3

Tio RA, Voorbij RH, Enthoven R

Adult respiratory distress syndrome after streptokinase.

The American journal of cardiology. 1992;70(20):1632-3