The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Arya P, Prickett KK, Raol N, Briones M, Evans S

Sirolimus-induced pulmonary hemorrhage of an infant with massive cervicofacial lymphatic malformation: A case report.

International journal of pediatric otorhinolaryngology. 2023;164:111404

Serifoglu I, Er Dedekarginoglu B, Ayvazoglu Soy EH, Ulubay G, Haberal M

Causes of Hemoptysis in Renal Transplant Patients.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 2018;16 Suppl 1(Suppl 1):70-74

Kirby S, Satoskar A, Brodsky S, Pope-Harman A, Nunley D, Hitchcock C, Pelletier R, Ross P, Nadasdy T, Shilo K

Histological spectrum of pulmonary manifestations in kidney transplant recipients on sirolimus inclusive immunosuppressive regimens.

Diagnostic pathology. 2012;7:25

Patel AV, Hahn T, Bogner PN, Loud PA, Brown K, Paplham P, Syta M, Battiwalla M, McCarthy PL

Fatal diffuse alveolar hemorrhage associated with sirolimus after allogeneic hematopoietic cell transplantation.

Bone marrow transplantation. 2010;45(8):1363-4

Rabe C, Appenrodt B, Hoff C, Ewig S, Klehr HU, Sauerbruch T, Nickenig G, Tasci S

Severe respiratory failure due to diffuse alveolar hemorrhage: clinical characteristics and outcome of intensive care.

Journal of critical care. 2010;25(2):230-5

Hashemi-Sadraei N, Sadrpour S, Baram D, Miller F, Nord EP

Sirolimus-associated diffuse alveolar hemorrhage in a renal transplant recipient on long-term anticoagulation.

Clinical nephrology. 2007;68(4):238-44

Khalife WI, Kogoj P, Kar B

Sirolimus-induced alveolar hemorrhage.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2007;26(6):652-7

Damas C, Oliveira A, Morais A

[Lung toxicity induced by rapamycin].

Revista portuguesa de pneumologia. 2006;12(6):715-24

Champion L, Stern M, Israël-Biet D, Mamzer-Bruneel MF, Peraldi MN, Kreis H, Porcher R, Morelon E

Brief communication: sirolimus-associated pneumonitis: 24 cases in renal transplant recipients.

Annals of internal medicine. 2006;144(7):505-9

Chhajed PN, Dickenmann M, Bubendorf L, Mayr M, Steiger J, Tamm M

Patterns of pulmonary complications associated with sirolimus.

Respiration; international review of thoracic diseases. 2006;73(3):367-74

Pham PT, Pham PC, Danovitch GM, Ross DJ, Gritsch HA, Kendrick EA, Singer J, Shah T, Wilkinson AH

Sirolimus-associated pulmonary toxicity.

Transplantation. 2004;77(8):1215-20

Vlahakis NE, Rickman OB, Morgenthaler T

Sirolimus-associated diffuse alveolar hemorrhage.

Mayo Clinic proceedings. 2004;79(4):541-5

Morelon E, Stern M, Israël-Biet D, Correas JM, Danel C, Mamzer-Bruneel MF, Peraldi MN, Kreis H

Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients.

Transplantation. 2001;72(5):787-90