The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIV.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Kirby S, Satoskar A, Brodsky S, Pope-Harman A, Nunley D, Hitchcock C, Pelletier R, Ross P, Nadasdy T, Shilo K

Histological spectrum of pulmonary manifestations in kidney transplant recipients on sirolimus inclusive immunosuppressive regimens.

Diagnostic pathology. 2012;7:25

Lee HS, Huh KH, Kim YS, Kim MS, Kim HJ, Kim SI, Joo DJ

Sirolimus-induced pneumonitis after renal transplantation: a single-center experience.

Transplantation proceedings. 2012;44(1):161-3

Morcos A, Nair S, Keane MP, McElvaney NG, McCormick PA

Interstitial pneumonitis is a frequent complication in liver transplant recipients treated with sirolimus.

Irish journal of medical science. 2012;181(2):231-5

Das S, Cherian SV, Das N, Garcha AS, Lenox R, Sexton J

Persistent dyspnea in a 59-year-old woman receiving immunosuppressants.

Chest. 2011;140(3):818-822

Flechner SM

Risk factors for and management of sirolimus-associated pneumonitis in kidney transplant recipients.

Nature clinical practice. Nephrology. 2008;4(5):250-1

Weiner SM, Sellin L, Vonend O, Schenker P, Buchner NJ, Flecken M, Viebahn R, Rump LC

Pneumonitis associated with sirolimus: clinical characteristics, risk factors and outcome--a single-centre experience and review of the literature.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2007;22(12):3631-7

Delgado JF, Torres J, José Ruiz-Cano M, Sánchez V, Escribano P, Borruel S, María Cortina J, de la Calzada CS

Sirolimus-associated interstitial pneumonitis in 3 heart transplant recipients.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2006;25(9):1171-4

Howard L, Gopalan D, Griffiths M, Mahadeva R

Sirolimus-induced pulmonary hypersensitivity associated with a CD4 T-cell infiltrate.

Chest. 2006;129(6):1718-21

Champion L, Stern M, Israël-Biet D, Mamzer-Bruneel MF, Peraldi MN, Kreis H, Porcher R, Morelon E

Brief communication: sirolimus-associated pneumonitis: 24 cases in renal transplant recipients.

Annals of internal medicine. 2006;144(7):505-9

Hamour IM, Mittal TK, Bell AD, Banner NR

Reversible sirolimus-associated pneumonitis after heart transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2006;25(2):241-4

Garrean S, Massad MG, Tshibaka M, Hanhan Z, Caines AE, Benedetti E

Sirolimus-associated interstitial pneumonitis in solid organ transplant recipients.

Clinical transplantation. 2005;19(5):698-703

Chhajed PN, Dickenmann M, Bubendorf L, Mayr M, Steiger J, Tamm M

Patterns of pulmonary complications associated with sirolimus.

Respiration; international review of thoracic diseases. 2006;73(3):367-74

Jiménez-Rivera C, Avitzur Y, Fecteau AH, Jones N, Grant D, Ng VL

Sirolimus for pediatric liver transplant recipients with post-transplant lymphoproliferative disease and hepatoblastoma.

Pediatric transplantation. 2004;8(3):243-8

Pham PT, Pham PC, Danovitch GM, Ross DJ, Gritsch HA, Kendrick EA, Singer J, Shah T, Wilkinson AH

Sirolimus-associated pulmonary toxicity.

Transplantation. 2004;77(8):1215-20

Haydar AA, Denton M, West A, Rees J, Goldsmith DJ

Sirolimus-induced pneumonitis: three cases and a review of the literature.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2004;4(1):137-9