The Drug-Induced Cardiotoxicity Website and App

Anticoagulants, direct oral (anti-thrombin, -IIa, -Xa) - NOAC

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXII.b

ARDS - Acute lung injury

First cases observed in Japan

Publications

Tomari S, Homma K, Noguchi T, Aiba T, Matsuki T, Suzuki R, Koga M, Takigami M, Tagawa H, Hashimoto T, Toyoda K

Development of Interstitial Lung Disease after Initiation of Apixaban Anticoagulation Therapy.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2016;25(7):1767-1769