The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXXV.b

Disordered breathing pattern incl. Cheyne-Stokes respiration

Publications

Lamberts V, Baele P, Kahn D, Liistro G

Dyspnea or Cheyne-Stokes respiration associated with Ticagrelor?

Sleep medicine. 2018;43:4-6

Conte L, Pugliese NR, Giannoni A

Reversal of Ticagrelor-Induced Arrhythmias and Cheyne-Stokes Respiration With Aminophylline Infusion.

Journal of cardiovascular pharmacology. 2017;70(5):290-292

Giannoni A, Emdin M, Passino C

Cheyne-Stokes Respiration, Chemoreflex, and Ticagrelor-Related Dyspnea.

The New England journal of medicine. 2016;375(10):1004-6