The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)

Likelihood and causality disputed (PMID 25343207)

Publications

İlgün JD, Keskin AT, Ateş S, Güler S

Sevoflurane-Induced Diffuse Alveolar Hemorrhage Following Strabismus Surgery: A Rare Event in the Emergency Department.

The Journal of emergency medicine. 2026;86:39-44

Jordan JH, Pedroza S, Billefals ES, Cruz G

Diffuse alveolar hemorrhage induced by inhaled Sevoflurane. Case report and literature review.

Respiratory medicine case reports. 2023;45:101906

Ahmed-Khan M, Moin K, Funk C, Sachdev M, Jiffry MZM

Sevoflurane-Induced Diffuse Alveolar Hemorrhage.

Archive of clinical cases. 2023;10(1):29-31

Yasli SO, Dogruel F, Demirbas AE, Canpolat DG

A case of diffuse alveolar hemorrhage after orthognathic surgery: Case report with the literature review'.

Nigerian journal of clinical practice. 2022;25(6):967-970

Mendonça MC, Abreu JB, Gama K

Diffuse Alveolar Hemorrhage After Orotracheal Extubation Probably Induced by Sevoflurane Inhalation.

Archivos de bronconeumologia. 2021

Murray AW, Smith JD, Ibinson JW

Diffuse alveolar hemorrhage, anesthesia, and cannabis.

Annals of the American Thoracic Society. 2014;11(8):1338-9

Kim CA, Liu R, Hsia DW

Diffuse alveolar hemorrhage induced by sevoflurane.

Annals of the American Thoracic Society. 2014;11(5):853-5