The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXVIII.a

Angioedema (may cause UAO, asphyxia and death)

Publications

Lee JE, Bryant SM

Unilateral angioedema.

The American journal of emergency medicine. 2021;49:302-303

Soo Hoo GW, Lin HK, Junaid I, Klaustermeyer WB

Angiotensin-converting Enzyme Inhibitor Angioedema Requiring Admission to an Intensive Care Unit.

The American journal of medicine. 2015;128(7):785-9

Cuculi F, Suter Y, Erne P

Angioedema of the tongue.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2008;178(9):1136