The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

Publications

Cappelletti S, Piacentino D, Fineschi V, Frati P, Cipolloni L, Aromatario M

Caffeine-Related Deaths: Manner of Deaths and Categories at Risk.

Nutrients. 2018;10(5)

Aknouche F, Guibert E, Tessier A, Eibel A, Kintz P

Suicide by ingestion of caffeine.

Egyptian journal of forensic sciences. 2017;7(1):6

Ciszowski K, Biedroń W, Gomólka E

Acute caffeine poisoning resulting in atrial fibrillation after guarana extract overdose.

Przeglad lekarski. 2014;71(9):495-8

Bioh G, Gallagher MM, Prasad U

Survival of a highly toxic dose of caffeine.

BMJ case reports. 2013;2013