The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

Publications

Badar F, Azeez H, Abdulrahman Z, Ashraf A, Iftikhar A

Anagrelide-Induced Supraventricular Tachycardia: A Case Report.

Cureus. 2022;14(6):e26119

Siddiqui MU, Siddiqui MD, Hameed S, Naeem Z, Siddiqui M

Platelet Anti-Aggregator Drowns the Heart.

South Dakota medicine : the journal of the South Dakota State Medical Association. 2021;74(11):502-505

James CW

Anagrelide-induced cardiomyopathy.

Pharmacotherapy. 2000;20(10):1224-7