The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXII.g

Respiratory acidosis - Hypercapnia

Publications

Hassanian-Moghaddam H, Farnaghi F, Rahimi M

Tramadol overdose and apnea in hospitalized children, a review of 20 cases.

Research in pharmaceutical sciences. 2015;10(6):544-52

Rahimi HR, Soltaninejad K, Shadnia S

Acute tramadol poisoning and its clinical and laboratory findings.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. 2014;19(9):855-9