The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Ozawa T, Terai H, Kajino A, Otake S, Saito A, Nishie M, Kishino Y, Kamata H, Hayashida K, Ishii M, Fukunaga K

Apixaban-Associated Diffuse Alveolar Hemorrhage in an Elderly Man with Multiple Complications.

The American journal of case reports. 2022;23:e937809

Papanikolaou IC, Makou I, Markatis E

Amiodarone and diffuse alveolar hemorrhage.

Advances in respiratory medicine. 2020;88(2):169-171

Gabrilovich MI, Buxton DE, Lykins DM, McMillen SM, Onadeko OOA

Diffuse alveolar hemorrhage secondary to apixaban administration.

Chest. 2014;146(3):e115-e116