The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIV.h

Pulmonary fibrosis

Publications

Segura A, Yuste A, Cercos A, López-Tendero P, Gironés R, Pérez-Fidalgo JA, Herranz C

Pulmonary fibrosis induced by cyclophosphamide.

The Annals of pharmacotherapy. 2001;35(7-8):894-7

Malik SW, Myers JL, DeRemee RA, Specks U

Lung toxicity associated with cyclophosphamide use. Two distinct patterns.

American journal of respiratory and critical care medicine. 1996;154(6 Pt 1):1851-6