The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Agarwal M, Cummings K, Larsen B, Chopra M, Rodriguez-Pla A

Late Onset of Rivaroxaban-Associated Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis.

Journal of investigative medicine high impact case reports. 2023;11:23247096231207689

Hammar SP

Fatal pulmonary hemorrhage after taking anticoagulation medication.

Respiratory medicine case reports. 2015;15:66-70

Wong A, Koutsogiannis Z, Greene SL

Pulmonary haemorrhage from therapeutic rivaroxaban use: chest radiograph consolidation is not always infection!

Emergency medicine Australasia : EMA. 2014;26(3):318-9