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The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIV.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Dias OM, Nascimento ECTD, Chate RC, Kairalla RA, Baldi BG

Eosinophilic pneumonia: remember topical drugs as a potential etiology.

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia. 2018;44(6):522-524

Klerkx S, Pat K, Wuyts W

Minocycline induced eosinophilic pneumonia: case report and review of literature.

Acta clinica Belgica. 2009;64(4):349-54

Ono E, Miyazaki E, Matsuno O, Nureki S, Okubo T, Ando M, Kumamoto T

Minocycline-induced acute eosinophilic pneumonia: controversial results of lymphocyte stimulation test and re-challenge test.

Internal medicine (Tokyo, Japan). 2007;46(9):593-5

Roca B, Calvo B, Ferrer D

Minocycline hypersensitivity reaction with acute respiratory distress syndrome.

Intensive care medicine. 2003;29(2):338

Nakano K, Gemma H, Ono T, Ito I, Chida K, Nakamura H

[A case of minocycline-induced eosinophilic pneumonia presenting with multiple white eosinophilic plaques in the tracheobronchial mucosa].

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2001;39(1):24-9

Piette AM, Ramanoelina J, Gepner P, Larroche C, Blétry O

[Systemic reaction induced my minocycline treatment: a report of four patients and a review of the literature].

La Revue de medecine interne. 1999;20(10):869-74

Hara H, Fujitsuka A, Morishima C, Kurihara N, Yamaguchi Z, Morishima T

Severe drug-induced pneumonitis associated with minocycline and nicotinamide therapy of a bullous pemphigoid.

Acta dermato-venereologica. 1998;78(5):393-4

Toyoshima M, Sato A, Hayakawa H, Taniguchi M, Imokawa S, Chida K

A clinical study of minocycline-induced pneumonitis.

Internal medicine (Tokyo, Japan). 1996;35(3):176-9

Bando T, Fujimura M, Noda Y, Hirose J, Ohta G, Matsuda T

Minocycline-induced pneumonitis with bilateral hilar lymphadenopathy and pleural effusion.

Internal medicine (Tokyo, Japan). 1994;33(3):177-9

Sitbon O, Bidel N, Dussopt C, Azarian R, Braud ML, Lebargy F, Fourme T, de Blay F, Piard F, Camus P

Minocycline pneumonitis and eosinophilia. A report on eight patients.

Archives of internal medicine. 1994;154(14):1633-40