The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXXVIII.d

Death following exposure or poisoning

Publications

Hobbs JM, DeRienz RT, Baker DD, Shuttleworth MR, Pandey M

Fatal Intoxication by the Novel Cathinone 4-Fluoro-3-methyl-α-PVP.

Journal of analytical toxicology. 2022;46(3):e101-e104

Yamagishi I, Minakata K, Nozawa H, Hasegawa K, Suzuki M, Kitamoto T, Suzuki O, Watanabe K

A case of intoxication with a mixture of synthetic cannabinoids EAM-2201, AB-PINACA and AB-FUBINACA, and a synthetic cathinone α-PVP.

Legal medicine (Tokyo, Japan). 2018;35:44-49

Sykutera M, Cychowska M, Bloch-Boguslawska E

A Fatal Case of Pentedrone and α-Pyrrolidinovalerophenone Poisoning.

Journal of analytical toxicology. 2015;39(4):324-9

Eiden C, Mathieu O, Cathala P, Debruyne D, Baccino E, Petit P, Peyriere H

Toxicity and death following recreational use of 2-pyrrolidino valerophenone.

Clinical toxicology (Philadelphia, Pa.). 2013;51(9):899-903

Murphy CM, Dulaney AR, Beuhler MC, Kacinko S

"Bath salts" and "plant food" products: the experience of one regional US poison center.

Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2013;9(1):42-8