The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIV.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Kampman A, Keulers L, der Maten JV, der Meij JV, Bethlehem C

A Severe Case of Isotretinoin Induced Eosinophilic Pneumonia and Pericardial Effusion, a Case Report.

Current drug safety. 2025;20(1):74-77

De Giacomi F, Decker PA, Vassallo R, Ryu JH

Acute Eosinophilic Pneumonia: Correlation of Clinical Characteristics With Underlying Cause.

Chest. 2017;152(2):379-385

Oliviero G, Constans P, Caby I, De Rohan Chabot P, Lacherade JC

[Lung disease induced by isotretinoin].

Revue des maladies respiratoires. 1995;12(6):631-3