The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXII.e

Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

Publications

Lyndon A, Audrey S, Wells C, Burnell ES, Ingle S, Hill R, Hickman M, Henderson G

Risk to heroin users of polydrug use of pregabalin or gabapentin.

Addiction (Abingdon, England). 2017;112(9):1580-1589

Wood DM, Berry DJ, Glover G, Eastwood J, Dargan PI

Significant pregabalin toxicity managed with supportive care alone.

Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2010;6(4):435-7