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The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)

Review articles at PMID�23672179 and�24224462

Publications

Ugajin M, Kani H, Hattori H

Anticoagulant Use as an Independent Risk Factor and Higher In-Hospital Mortality in Patients Showing Alveolar Hemorrhage in Diffuse Lung Disease.

Medicina (Kaunas, Lithuania). 2021;57(10)

Shiroshita A, Nakashima K, Tanaka Y, Tateishi A, Nemoto M, Aoshima M

Successful treatment with idarucizumab for diffuse alveolar hemorrhage induced by dabigatran etexilate: a case report.

Journal of thrombosis and thrombolysis. 2018;46(2):271-273

Nitta K, Imamura H, Yashio A, Kashima S, Mochizuki K

Diffuse Alveolar Hemorrhage Associated with Edoxaban Therapy.

Case reports in critical care. 2016;2016:7938062

Chen BC, Sheth NR, Dadzie KA, Smith SW, Nelson LS, Hoffman RS, Winchester JF

Hemodialysis for the treatment of pulmonary hemorrhage from dabigatran overdose.

American journal of kidney diseases : the official journal of the National Kidney Foundation. 2013;62(3):591-4

Yokoi K, Isoda K, Kimura T, Adachi T

Diffuse alveolar hemorrhage associated with dabigatran.

Internal medicine (Tokyo, Japan). 2012;51(18):2667-8

Husari A, Beydoun A, Sheik Ammar A, Maakaron JE, Taher A

The untold story of Dabigatran etexilate: alveolar hemorrhage in an elderly patient with interstitial pulmonary fibrosis.

Journal of thrombosis and thrombolysis. 2013;35(1):81-2