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The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Left or biventricular dysfunction/failure

Publications

Samanci NS, Guliyev M, Degerli E, Celik E, Turna ZH

A rare case of cardiac toxicity in a patient with imatinib treatment: Case report.

Journal of cancer research and therapeutics. 2022;18(3):792-794

Ran HH, Zhang R, Lu XC, Yang B, Fan H, Zhu HL

Imatinib-induced decompensated heart failure in an elderly patient with chronic myeloid leukemia: case report and literature review.

Journal of geriatric cardiology : JGC. 2012;9(4):411-4

Breccia M

Is imatinib-related cardiotoxicity still an open issue?

Leukemia research. 2011;35(1):34-5