The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIII.a

Methemoglobinemia

Publications

Sikka P, Bindra VK, Kapoor S, Jain V, Saxena KK

Blue cures blue but be cautious.

Journal of pharmacy & bioallied sciences. 2011;3(4):543-5

McRobb CM, Holt DW

Methylene blue-induced methemoglobinemia during cardiopulmonary bypass? A case report and literature review.

The journal of extra-corporeal technology. 2008;40(3):206-14