The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIV.b

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)

Publications

Moureau G, Zarrouk E, Hoton D, Saint-Marcoux F, Boland L, Haufroid V, Hantson P

Flecainide-induced pneumonitis: a case report.

Journal of medical case reports. 2022;16(1):404

Huang HD, Pietrasik GM, Serafini NJ, Sharma PS, Krishnan K, Trohman RG

Drug-induced acute pneumonitis following initiation of flecainide therapy after pulmonary vein isolation ablation in a patient with mitral stenosis and previous chronic amiodarone use.

HeartRhythm case reports. 2019;5(1):53-55

Robain A, Perchet H, Fuhrman C

Flecainide-associated pneumonitis with acute respiratory failure in a patient with the LEOPARD syndrome.

Acta cardiologica. 2000;55(1):45-7

Hanston P, Evrard P, Mahieu P, Wallemacq P, Friob M, Hassoun A

Flecainide-associated interstitial pneumonitis.

Lancet (London, England). 1991;337(8737):371-2