The Drug-Induced Cardiotoxicity Website and App
Frequency - Incidence
Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Methemoglobinemia
Publications
Dapsone-Induced Methemoglobinemia in a Woman With Multiple Myeloma Without Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency.
Cureus. 2024;16(6):e63249
Detection of methaemoglobinaemia in a COVID-19 patient on dapsone.
BMJ case reports. 2024;17(1)
Efficacy of dual intracerebroventricular and intravitreal CLN5 gene therapy in sheep prompts the first clinical trial to treat CLN5 Batten disease.
Frontiers in pharmacology. 2023;14:1212235
A Chest Pain Conundrum: Dapsone-Induced Methemoglobinemia in a Heart Transplant Patient.
Cureus. 2023;15(10):e46690
Methemoglobinemia With Dapsone Prophylaxis in a Patient With Minimal Change Disease.
Cureus. 2022;14(6):e26393
Methylene Blue Infusion to Treat Severe Dapsone-Induced Methemoglobinemia in a Pediatric Patient.
Cureus. 2021;13(10):e18853
[Methemoglobinemia caused by dapsone. Report of one case].
Revista medica de Chile. 2020;148(12):1838-1843
A Case of Dapsone-induced Mild Methemoglobinemia with Dyspnea and Cyanosis.
Acta dermatovenerologica Croatica : ADC. 2020;28(4):249-250
Unusual cause of persistent dyspnea in a patient with nephrotic syndrome: dapsone-induced methemoglobinemia.
CEN case reports. 2021;10(3):336-340
A case of dapsone-induced methaemoglobinaemia.
Clinical medicine (London, England). 2020;20(5):519-521
A case of DAPSONE INDUCED METHEMOGLOBINEMIA.
Journal of pharmaceutical policy and practice. 2019;12:22
Dapsone-induced Methemoglobinemia in a Patient of Leprosy.
Indian journal of dermatology. 2015;60(1):108
Mitsides N, Green D, Middleton R, New D, Lamerton E, Allen J, Redshaw J, Chadwick PR, Subudhi CP, Wood G
Dapsone-induced methemoglobinemia in renal transplant recipients: more prevalent than previously thought.
Transplant infectious disease : an official journal of the Transplantation Society. 2014;16(1):37-43
Dapsone-induced methemoglobinemia: a primer for clinicians.
The Annals of pharmacotherapy. 2011;45(9):1103-15
Symptomatic-low grade methemoglobinemia because of dapsone: a multiple hit hypothesis.
American journal of therapeutics. 2013;20(6):e729-32
Case files of the medical toxicology fellowship at Banner Good Samaritan Medical Center in Phoenix, AZ: methemoglobinemia following dapsone exposure.
Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2011;7(2):139-46
Case records of the Massachusetts General Hospital: Case 7-2011: a 52-year-old man with upper respiratory symptoms and low oxygen saturation levels.
The New England journal of medicine. 2011;364(10):957-66
Dapsone-induced methemoglobinemia: a dose-related occurrence?
Cancer. 2011;117(15):3485-92
Dyspnea in a lung transplant recipient.
Respiratory care. 2010;55(5):626-9
Pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia.
The Journal of the American Osteopathic Association. 2010;110(1):16-20
Dapsone-induced hemolytic anemia in lung allograft recipients.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2008;27(11):1198-202
Dapsone induced methemoglobinemia : Intermittent vs continuous intravenous methylene blue therapy.
Indian journal of pediatrics. 2008;75(3):245-7
Methemoglobinemia associated with dapsone therapy in a child with pneumonia and chronic immune thrombocytopenic purpura.
Journal of pediatric hematology/oncology. 2006;28(6):395-8
Presentation of dapsone-induced methemoglobinemia in a patient status post small bowel transplant.
Journal of clinical anesthesia. 2005;17(7):568-70
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals.
Medicine. 2004;83(5):265-273
Dapsone-induced methemoglobinemia in pediatric oncology patients: case examples.
Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses. 2001;18(5):224-8
[Respiratory insufficiency caused by dapsone-induced methemoglobinemia].
Ugeskrift for laeger. 2001;163(1):39-40
Blue and breathless.
Hospital medicine (London, England : 1998). 1999;60(7):530
Acute dapsone intoxication: a pediatric case report.
Pediatric emergency care. 1997;13(2):127-9
Drug-induced methaemoglobinaemia. Treatment issues.
Drug safety. 1996;14(6):394-405
Safrin S, Finkelstein DM, Feinberg J, Frame P, Simpson G, Wu A, Cheung T, Soeiro R, Hojczyk P, Black JR
Comparison of three regimens for treatment of mild to moderate Pneumocystis carinii pneumonia in patients with AIDS. A double-blind, randomized, trial of oral trimethoprim-sulfamethoxazole, dapsone-trimethoprim, and clindamycin-primaquine. ACTG 108 Study
Annals of internal medicine. 1996;124(9):792-802
Methemoglobinemia provoked by malarial chemoprophylaxis in Vietnam.
The New England journal of medicine. 1968;279(21):1127-31
Respiratory insufficiency from dapsone-induced methemoglobinemia.
AIDS (London, England). 1991;5(11):1392-3