The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIII.a

Methemoglobinemia

Publications

Di Fenza R, Shetty NS, Gianni S, Parcha V, Giammatteo V, Safaee Fakhr B, Tornberg D, Wall O, Harbut P, Lai PS, Li JZ, Paganoni S, Cenci S, Mueller AL, Houle TT, Akeju O, Bittner EA, Bose S, Scott LK, Carroll RW, Ichinose F, Hedenstierna M, Arora P, Berra

High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure Due to COVID-19: A Multicenter Phase II Trial.

American journal of respiratory and critical care medicine. 2023;208(12):1293-1304

Syed AU, Jelly AE, Algebaly AA, Altoonisi MM, Shatoory AE

Methemoglobinemia due to nitric oxide therapy in a child after cardiac surgery.

Asian cardiovascular & thoracic annals. 2013;21(3):345-7

Rolley L, Bandeshe H, Boots RJ

'Safe' methaemoglobin concentrations are a mortality risk factor in patients receiving inhaled nitric oxide.

Anaesthesia and intensive care. 2011;39(5):919-25

Sinisterra S, Miravet E, Alfonso I, Soliz A, Papazian O

Methemoglobinemia in an infant receiving nitric oxide after the use of eutectic mixture of local anesthetic.

The Journal of pediatrics. 2002;141(2):285-6

Salguero KL, Cummings JJ

Inhaled nitric oxide and methemoglobin in full-term infants with persistent pulmonary hypertension of the newborn.

Pulmonary pharmacology & therapeutics. 2002;15(1):1-5

Weinberger B, Laskin DL, Heck DE, Laskin JD

The toxicology of inhaled nitric oxide.

Toxicological sciences : an official journal of the Society of Toxicology. 2001;59(1):5-16

Hovenga S, Koenders ME, van der Werf TS, Moshage H, Zijlstra JG

Methaemoglobinaemia after inhalation of nitric oxide for treatment of hydrochlorothiazide-induced pulmonary oedema.

Lancet (London, England). 1996;348(9033):1035-6