The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.b

Pericardial effusion (w/wo tamponade)

Publications

Meng L, Deng B, Liu B, Gordon D

Association of sirolimus with pericardial effusion in renal transplant patient and discussion of potential mechanism.

BMJ case reports. 2019;12(7)

Joo SJ, Yildirim I, Stenger EO, Anderson EJ

Sirolimus-associated pericardial effusion with cardiac tamponade and interstitial pneumonitis in a hematopoietic stem cell transplant recipient.

Pediatric transplantation. 2019;23(4):e13425

Bertrand D, Desbuissons G, Pallet N, Debure A, Sartorius A, Anglicheau D, Mamzer MF, Legendre C, Sberro-Soussan R

Sirolimus therapy may cause cardiac tamponade.

Transplant international : official journal of the European Society for Organ Transplantation. 2013;26(2):e4-7