The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.a

Coronary artery disease (acute) - Myocardial ischemia/infarction

Publications

Hack JB

Oral sumatriptan-induced myocardial infarction.

Journal of toxicology. Clinical toxicology. 2004;42(3):309-11

Ottervanger JP, Wilson JH, Stricker BH

Drug-induced chest pain and myocardial infarction. Reports to a national centre and review of the literature.

European journal of clinical pharmacology. 1997;53(2):105-10

Stricker BH, Ottervanger JP, van der Klauw MM

[Registration of suspected adverse effects by the Bureau Adverse Effects Drugs; research activities in 1993].

Nederlands tijdschrift voor geneeskunde. 1994;138(42):2110-3