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The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XI.a

Pulmonary arterial hypertension

Publications

Ling Y, Johnson MK, Kiely DG, Condliffe R, Elliot CA, Gibbs JS, Howard LS, Pepke-Zaba J, Sheares KK, Corris PA, Fisher AJ, Lordan JL, Gaine S, Coghlan JG, Wort SJ, Gatzoulis MA, Peacock AJ

Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: results from the pulmonary hypertension registry of the United Kingdom and Ireland.

American journal of respiratory and critical care medicine. 2012;186(8):790-6

Natali D, Girerd B, Montani D, Soubrier F, Simonneau G, Humbert M, Sitbon O

Pulmonary arterial hypertension in a patient with Cowden syndrome and anorexigen exposure.

Chest. 2011;140(4):1066-1068

Souza R, Humbert M, Sztrymf B, Jaïs X, Yaïci A, Le Pavec J, Parent F, Hervé P, Soubrier F, Sitbon O, Simonneau G

Pulmonary arterial hypertension associated with fenfluramine exposure: report of 109 cases.

The European respiratory journal. 2008;31(2):343-8

Goldstein SE, Levy Y, Shoenfeld Y

[Development of pulmonary hypertension and multi-valvular damage caused by appetite depressants].

Harefuah. 1998;135(11):489-92, 568

Rich S, Rubin L, Walker AM, Schneeweiss S, Abenhaim L

Anorexigens and pulmonary hypertension in the United States: results from the surveillance of North American pulmonary hypertension.

Chest. 2000;117(3):870-4

Rothman RB, Ayestas MA, Dersch CM, Baumann MH

Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension.

Circulation. 1999;100(8):869-75

Louis WJ

Primary pulmonary hypertension and anorectic drugs.

The New England journal of medicine. 1999;340(6):480-2

Simonneau G, Fartoukh M, Sitbon O, Humbert M, Jagot JL, Hervé P

Primary pulmonary hypertension associated with the use of fenfluramine derivatives.

Chest. 1998;114(3 Suppl):195S-199S

Delcroix M, Kurz X, Walckiers D, Demedts M, Naeije R

High incidence of primary pulmonary hypertension associated with appetite suppressants in Belgium.

The European respiratory journal. 1998;12(2):271-6

Kramer MS, Lane DA

Aminorex, dexfenfluramine, and primary pulmonary hypertension.

Journal of clinical epidemiology. 1998;51(4):361-4

Abenhaim L, Moride Y, Brenot F, Rich S, Benichou J, Kurz X, Higenbottam T, Oakley C, Wouters E, Aubier M, Simonneau G, Bégaud B

Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group.

The New England journal of medicine. 1996;335(9):609-16