The Drug-Induced Cardiotoxicity Website and App

Hemotherapy (transfusion/infusion of whole blood, red cells, platelets, or blood products)

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Jin SM, Jang MJ, Huh JY, Park MH, Song EY, Oh D

A case of transfusion-related acute lung injury induced by anti-human leukocyte antigen antibodies in acute leukemia.

The Korean journal of hematology. 2012;47(4):302-6

Darabi K, Abdel-Wahab O, Stowell C, Sepehr A

An 87-year-old woman with respiratory distress and alveolar hemorrhage after transfusion.

Chest. 2006;130(5):1612-6