The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXIX.a

Bronchospasm - Wheezing - Asthma

There is evidence of transient drop in FEV1 following inhalation, that may be due to vehilce. There is statistical evidence for an increased incidence of severe asthma requiring MV in B2-agonists users

Publications

Shin HJ, Kim TO, Kim YI, Kim SH, Kim HK, Kim YH, Byun MK, Jung KS, Yoo KH, Lee JS, Lim SC, KOCOSS Cohort Study Group

The paradoxical response to short-acting bronchodilator administration in patients with chronic obstructive pulmonary disease.

Journal of thoracic disease. 2021;13(2):511-520

Robles J, Motheral L

Hypersensitivity reaction after inhalation of a lactose-containing dry powder inhaler.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG. 2014;19(3):206-11

Boucher A, Payen C, Garayt C, Ibanez H, Dieny A, Doche C, Chuniaud C, Descotes J

Salbutamol misuse or abuse with fatal outcome: a case-report.

Human & experimental toxicology. 2011;30(11):1869-71

Peters J

ACP Journal Club: beta-agonists increase asthma-related intubations and deaths in patients with asthma.

Annals of internal medicine. 2010;153(6):JC3-5

Mutlu GM, Moonjelly E, Chan L, Olopade CO

Laryngospasm and paradoxical bronchoconstriction after repeated doses of beta 2-agonists containing edetate disodium.

Mayo Clinic proceedings. 2000;75(3):285-7

Facchini G, Antonicelli L, Cinti B, Bonifazi F, Massei V

Paradoxical bronchospasm and cutaneous rash after metered-dose inhaled bronchodilators.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace. 1996;51(3):201-3

Arne M, Sjölund K

[Paradoxal reaction in an asthma patient after inhalation of terbutaline].

Lakartidningen. 1985;82(3):120-1