The Drug-Induced Cardiotoxicity Website and App
Frequency - Incidence
Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)
Publications
Safety-related regulatory actions for biologicals approved in the United States and the European Union.
JAMA. 2008;300(16):1887-96
Management and preparedness for infusion and hypersensitivity reactions.
The oncologist. 2007;12(5):601-9
Tada K, Ito Y, Hatake K, Okudaira T, Watanabe J, Arakawa M, Miyazato M, Irie T, Mizunuma N, Takahashi S, Aiba K, Horikoshi N, Kasumi F
Severe infusion reaction induced by trastuzumab: a case report.
Breast cancer (Tokyo, Japan). 2003;10(2):167-9