The Drug-Induced Cardiotoxicity Website and App
Frequency - Incidence
Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Cyanosis, a low SpO2 and normal measured PaO2
See under XIVa: Methemoglobinemia
Publications
The mystery of 'saturation gap': a case of dapsone-induced methaemoglobinemia in a pregnant mother with leprosy.
Oxford medical case reports. 2019;2019(1):omy111
Dapsone-induced methemoglobinemia: a primer for clinicians.
The Annals of pharmacotherapy. 2011;45(9):1103-15
Case records of the Massachusetts General Hospital: Case 7-2011: a 52-year-old man with upper respiratory symptoms and low oxygen saturation levels.
The New England journal of medicine. 2011;364(10):957-66
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals.
Medicine. 2004;83(5):265-273
Blue and breathless.
Hospital medicine (London, England : 1998). 1999;60(7):530
A case of methemoglobinemia after ingestion of an aphrodisiac, later proven as dapsone.
Yonsei medical journal. 1999;40(4):388-91
Safrin S, Finkelstein DM, Feinberg J, Frame P, Simpson G, Wu A, Cheung T, Soeiro R, Hojczyk P, Black JR
Comparison of three regimens for treatment of mild to moderate Pneumocystis carinii pneumonia in patients with AIDS. A double-blind, randomized, trial of oral trimethoprim-sulfamethoxazole, dapsone-trimethoprim, and clindamycin-primaquine. ACTG 108 Study
Annals of internal medicine. 1996;124(9):792-802