The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

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DRES syndrome - DRESS-like reaction

Publications

Kinehara Y, Kijima T, Inoue K, Hirata H, Takeuchi Y, Fukushima K, Hayama Y, Higashiguchi M, Morimura O, Miyake K, Minami T, Nagatomo I, Takeda Y, Kida H, Kumanogoh A

Dapsone hypersensitivity syndrome-related lung injury without eosinophilia in the bronchoalveolar lavage fluid.

Internal medicine (Tokyo, Japan). 2015;54(7):827-31

Choi SY, Hwang HY, Lee JH, Park JS, Jang MS

Severe dapsone hypersensitivity syndrome in a child.

Korean journal of pediatrics. 2013;56(6):260-4

Tian W, Shen J, Zhou M, Yan L, Zhang G

Dapsone hypersensitivity syndrome among leprosy patients in China.

Leprosy review. 2012;83(4):370-7

Kim GW, Park HJ, Kim HS, Kim SH, Ko HC, Kim BS, Kim MB

Dapsone Hypersensitivity Syndrome That Occurred during Treatment of Pediatric Patient with Erythema Elevatum Diutinum.

Annals of dermatology. 2011;23(Suppl 3):S290-5

Chen YC, Chiu HC, Chu CY

Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases.

Archives of dermatology. 2010;146(12):1373-9

Derungs A, Rätz Bravo AE, Kummer O

[Rash, fever, eosinophilia and elevated liver enzymes. DRESS syndrome (drug reaction or rash with eosinophilia and systemic symptoms)].

Praxis. 2010;99(13):767-77; quiz 776

Kosseifi SG, Guha B, Nassour DN, Chi DS, Krishnaswamy G

The Dapsone hypersensitivity syndrome revisited: a potentially fatal multisystem disorder with prominent hepatopulmonary manifestations.

Journal of occupational medicine and toxicology (London, England). 2006;1:9