The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XIV.a

Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

Publications

Kosseifi SG, Guha B, Nassour DN, Chi DS, Krishnaswamy G

The Dapsone hypersensitivity syndrome revisited: a potentially fatal multisystem disorder with prominent hepatopulmonary manifestations.

Journal of occupational medicine and toxicology (London, England). 2006;1:9

Corp CC, Ghishan FK

The sulfone syndrome complicated by pancreatitis and pleural effusion in an adolescent receiving dapsone for treatment of acne vulgaris.

Journal of pediatric gastroenterology and nutrition. 1998;26(1):103-5

Pang JA

Non-cardiogenic pulmonary oedema associated with pyrimethamine.

Respiratory medicine. 1989;83(3):247-8