The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.b

Pericardial effusion (w/wo tamponade)

Publications

Takekosh D, Nemoto T, Saito S, Matsui Y, Minagawa S, Hara H, Numata T, Araya J, Kuwano K

Minoxidil-induced lung disease, masquerading as hypersensitivity pneumonitis.

Respiratory medicine case reports. 2023;43:101861

Çilingiroğlu M, Akkuş N, Sethi S, Modi KA

Large pericardial effusion induced by minoxidil.

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir. 2012;40(3):255-8

Nautiyal A, Wong T, Kumar S, Mukherjee JT, Schick EC

Very large incidental pericardial effusion attributable to minoxidil: resolution without drainage.

Journal of cardiovascular medicine (Hagerstown, Md.). 2011;12(3):186-8

Houston MC, McChesney JA, Chatterjee K

Pericardial effusion associated with minoxidil therapy.

Archives of internal medicine. 1981;141(1):69-71

Webb DB, Whale RJ

Pleuropericardial effusion associated with minoxidil administration.

Postgraduate medical journal. 1982;58(679):319-20

Evans CW, Tucker SC

Pericarditis: a complication of minoxidil therapy.

Southern medical journal. 1983;76(6):815-6