The Drug-Induced Cardiotoxicity Website and App
Frequency - Incidence
Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Cardiomyopathy (acute, subacute, chronic)
Review on PMID 29858838
Publications
Cardiac Complications Attributed to Chloroquine and Hydroxychloroquine: A Systematic Review of the Literature.
Drug safety. 2018;41(10):919-931
Saussine A, Loriot MA, Picard C, Lecerf V, Landry J, Scheer I, Voicu S, Leenhardt A, Ducrocq G, Maubec E, Crickx B
[Chloroquine cardiotoxicity in long-term lupus therapy in two patients].
Annales de dermatologie et de venereologie. 2009;136(6-7):530-5
Chloroquine related cardiac toxicity.
The Journal of rheumatology. 1998;25(6):1221-5