The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XXXVI.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Vogiatzis I, Koulouris E, Sidiropoulos A, Giannakoulas C

Acute pulmonary edema after a single oral dose of acetazolamide.

Hippokratia. 2013;17(2):177-9

Gallerani M, Manzoli N, Fellin R, Simonato M, Orzincolo C

Anaphylactic shock and acute pulmonary edema after a single oral dose of acetazolamide.

The American journal of emergency medicine. 2002;20(4):371-2

Tzanakis N, Metzidaki G, Thermos K, Spyraki CH, Bouros D

Anaphylactic shock after a single oral intake of acetazolamide.

The British journal of ophthalmology. 1998;82(5):588