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The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.e

Overload pulmonary edema (including posttransfusional (TACO))

Transfusion-associated circulatory overload, a.k.a. TACO

Publications

Gosmann F, Nørgaard A, Rasmussen MB, Rahbek C, Seeberg J, Møller T

Transfusion-associated circulatory overload in adult, medical emergency patients with perspectives on early warning practice: a single-centre, clinical study.

Blood transfusion = Trasfusione del sangue. 2018;16(2):137-144

Ferreira CH, Carmona F, Martinez FE

Prevalence, risk factors and outcomes associated with pulmonary hemorrhage in newborns.

Jornal de pediatria. 2014;90(3):316-22

Menis M, Anderson SA, Forshee RA, McKean S, Johnson C, Holness L, Warnock R, Gondalia R, Worrall CM, Kelman JA, Ball R, Izurieta HS

Transfusion-associated circulatory overload (TACO) and potential risk factors among the inpatient US elderly as recorded in Medicare administrative databases during 2011.

Vox sanguinis. 2014;106(2):144-52

Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P, TRALI Study Group

Risk factors and outcomes in transfusion-associated circulatory overload.

The American journal of medicine. 2013;126(4):357.e29-38

Narick C, Triulzi DJ, Yazer MH

Transfusion-associated circulatory overload after plasma transfusion.

Transfusion. 2012;52(1):160-5

Li G, Rachmale S, Kojicic M, Shahjehan K, Malinchoc M, Kor DJ, Gajic O

Incidence and transfusion risk factors for transfusion-associated circulatory overload among medical intensive care unit patients.

Transfusion. 2011;51(2):338-43

Popovsky MA

Pulmonary consequences of transfusion: TRALI and TACO.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 2006;34(3):243-4