The Drug-Induced Cardiotoxicity Website and App
Frequency - Incidence
Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Anaphylaxis-Anaphylactoid reaction (can be fatal)
Publications
Successful eradication of inhibitor in a patient with severe haemophilia B and anaphylaxis to factor IX concentrates: is there a role for Rituximab and desensitization therapy?
Haemophilia : the official journal of the World Federation of Hemophilia. 2013;19(6):e382-5
Adverse effects of plasma transfusion.
Transfusion. 2012;52 Suppl 1(Suppl 1):65S-79S
Risks of transfusion.
Southern medical journal. 2011;104(11):762-9
Anaphylaxis from passive transfer of peanut allergen in a blood product.
The New England journal of medicine. 2011;364(20):1981-2
Leone R, Conforti A, Venegoni M, Motola D, Moretti U, Meneghelli I, Cocci A, Sangiorgi Cellini G, Scotto S, Montanaro N, Velo G
Drug-induced anaphylaxis : case/non-case study based on an italian pharmacovigilance database.
Drug safety. 2005;28(6):547-56
[Lethal anaphylactic shock during the transfusion of a thrombocyte concentrate].
Schweizerische medizinische Wochenschrift. 1966;96(28):918-20