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The Drug-Induced Cardiotoxicity Website and App

Frequency - Incidence

Incidence of cardiac adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for cardiac adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.b

Pulmonary edema, noncardiogenic (NCPE)

Publications

Sachs UJ

Recent insights into the mechanism of transfusion-related acute lung injury.

Current opinion in hematology. 2011;18(6):436-42

Sihler KC, Napolitano LM

Complications of massive transfusion.

Chest. 2010;137(1):209-20

Triulzi DJ

Transfusion-related acute lung injury: current concepts for the clinician.

Anesthesia and analgesia. 2009;108(3):770-6